乔娟
乔娟，女，理学博士，教授，博士生导师，北京石油化工学院新材料与化工学院生物制药专业责任教授。2002年毕业于河北大学化学与环境科学学院，获学士学位；2005年毕业于河北大学化学与环境科学学院，获硕士学位；2010年毕业于中国科学院化学研究所，获博士学位；2010-2022任中科院化学所助理研究员/副研究员；2016-2023兼任中国科学院大学化学科学学院岗位教师；2017- 2018在美国马萨诸塞大学阿默斯特分校国家公派访学。
从事聚合物的制备及生物药物分析应用研究。作为项目负责人承担和完成国家及北京市自然科学基金项目5项；以第一作者/通讯作者发表 SCI论文27篇，申请专利3项；参编专著2部；获中国分析测试协会科学技术奖一等奖2项。兼任北京色谱协会理事以及多个国内外专业期刊审稿人。
I. 主要研究工作
1. 毛细管电泳手性药物分析研究
2. 温敏荧光聚合物的制备及其细胞内温度成像应用研究
3. 靶向识别/原位可控聚合物酶反应器的制备及其蛋白酶解研究
II. 奖励与荣誉
1. 齐莉，乔娟，木肖玉，李楠，陈义. 构建聚合物分子温度计及其细胞成像应用研究，中国分析测试协会科学技术奖一等奖，2016年。
2. 齐莉，乔娟，张海枝，姚春荷，沈莹，木肖玉，张荣月，辛培勇，魏晓奕，李雅萍，陈义. 基于蛋白质及手性氨基酸分析的生物色谱新方法研究，中国分析测试协会科学技术奖一等奖，2012年。
III. 承担科研项目
1. 北京市自然科学基金面上项目：神经递质对映体的手性共价有机框架毛细管电泳分离研究（2242005），项目负责人
2. 国家自然科学基金面上项目：靶向识别细胞表面糖蛋白及其原位可控酶解（22074148），项目负责人
3. 国家自然科学基金重大研究计划培育项目：情感和记忆过程中温度与神经递质变化研究（91732103），项目负责人
4. 国家自然科学基金面上项目：刺激响应型聚合物多孔膜酶反应器的制备及其蛋白酶解研究（21475137），项目负责人
5. 国家自然科学基金青年基金项目：温敏荧光嵌段聚合物的制备及其在细胞内的温敏应用研究（21205125），项目负责人
6. 北京石油化工学院致远科研基金：NIR-II荧光聚合物及其亚细胞器温度变化研究（2024004），项目负责人
7. 化学所培育项目：荧光温敏聚合物制备及Ca2+通道调控细胞温度变化研究（CMS-PY-201355），项目负责人
8. 分子科学中心创新项目：整体柱酶反应器及氨基酸代谢的微流控芯片电泳研究（CX-201023），项目负责人
IV. 代表性学术论文
1. Yan Zhang, Zexi Yu, Xiaotong Zhu, Rongyue Zhang, Nan Li, Min Wang, Juan Qiao *. γ-cyclodextrin based metal organic framework as micellar electrokinetic chromatography additive for the chiral separation of dansylated amino acids, Journal of Chromatography B, 2026:1268, 124839.
2. Shufan Ge, Xiaotong Zhu, Chuanfang Chen, Rongyue Zhang, Min Wang, Nan Li, Xiaonan He, Juan Qiao*, Fluorescence polymer thermometer for the real-time mitochondrial temperature imaging of zebrafish embryos and larvae, Dyes and Pigments, 2026, 246, 113309.
3. Xiaotong Zhu, Xinyu Li, Haozhe Liu, Rongyue Zhang, Nan Li, Min Wang, Xiaonan He, Yunliang He, Juan Qiao*, A fluorescence-colorimetric dual-signal sensing platform based on arginine@ATT-AuNCs for ascorbic acid metabolic analysis in mice, Microchemical Journal 2025, 218, 115777.
4. Meng Yang, Xiaotong Zhu, Rongyue Zhang, Zhenwen Zhao, Li Qi, Min Wang, Nan Li, Juan Qiao*, Construction of AuNCs@MOF and Lead Ions Metabolic Analysis in Rat Serum, Inorganic Chemistry Communications, 2025, 178, 114517.
5. Xiaotong Zhu, Xinyu Li, Li Qi, Rongyue Zhang, Nan Li, Xiaonan He, Juan Qiao*, Protein@AuNPs synthesized by microfluidic droplet system and application in Cu(II) and L-Cysteine sensing[J], Chemical Research in Chinese Universities, 2025, 41, 131-137.
6. Xiaotong Zhu, Rongyue Zhang, Yucong Wang, Hongxia Jia*, Juan Qiao*, Fluorescence-enhanced MOF-encapsulated AuNCs for highly sensitive detection of melanin[J], Inorganic Chemistry Communications, 2024, 113226.
7. Juan Qiao, § Cheng Cheng, § Dan Li, Li Qi*, Thermo-responsive polymer-modified metal–organic frameworks as soft–rigid enzyme-reactors for enhancement of enzymolysis efficiency using a controllable embedding protocol[J], Journal of Materials Chemistry B, 2023, 11, 6428.
8. Juan Qiao,§ Qian Ma,§ Cheng Cheng, and Li Qi*, Fabrication of Dual-Stimuli-Responsive Polymer Vesicles for Regulation of Enzymolysis Efficiency in A Cascade Reaction[J], Chemistry An Asian Journal, 2023, 18, e202300285.
9. Juan Qiao,§ Xinya Zhang,§ Cheng Cheng, Li Qi*, Thermo-sensitive Porous Polymer Membrane-immobilized Cellulose as a Switchable Enzyme Reactor for Tuning Its Enzymolysis via Variation Temperature[J], Chemical Research in Chinese Universities, 2023, 39(6), 992-997.
10. Juan Qiao, Qian Ma, Xiangfei Li, Li Qi*, Redox-responsive polymer nanoreactors based on methionine sulfoxide for monitoring cell adhesion [J]. Analytical Chemistry, 2022, 94, 11807-11812.
11. Juan Qiao, Xiangfei Li, Li Qi*, Fluorescent polymer-modified gold nanobipyramids for temperature sensing during photothermal therapy in living cells [J]. Chinese Chemical Letters, 2022, 33, 3193-3196.
12. Juan Qiao, Yuying Song, Chuanfang Chen, Li Qi*, In situ determination of sialic acid on cell-surface with pH-regulated polymer enzyme nanoreactor [J]. Analytical Chemistry, 2021, 93, 7317-7322.
13. Juan Qiao, Deyu Wu, Yuying Song, Wenliang Ji, Qingwei Yue, Lanqun Mao, Li Qi*, Simultaneous monitoring of intracellular temperature and norepinephrine variation by fluorescent probes during norepinephrine reuptake [J]. Analytical Chemistry, 2021, 93, 14743-14747.
14. Juan Qiao, Lili Liu, Ji Shen, Li Qi*, Enzyme immobilization on a pH-responsive porous polymer membrane for enzymatic kinetics study [J]. Chinese Chemical Letters, 2021, 32, 3195-3198.
15. Juan Qiao, Li Qi*, Recent progress in plant-gold nanoparticles fabrication methods and bioapplications [J]. Talanta, 2021, 223, 121396.
16. Juan Qiao, Han Wu, Huan Wei, Lanqun Mao, Tie Wang, Li Qi*, Selective capture and in-situ controllable detection of D-glucose in cerebral systems [J]. Analytical Chemistry, 2020, 92, 4445-4450.
17. Juan Qiao, Yoon-Ho Hwang, Dong-Pyo Kim, Li Qi*, Simultaneous monitoring of temperature and Ca2+ concentration variation by fluorescent polymer during intracellular heat production [J]. Analytical Chemistry, 2020, 92, 8579-8583.
18. Juan Qiao, Junfang Jiang, Lili Liu, Ji Shen, Li Qi*, Enzyme reactor based on reversible pH controlled catalytic polymer porous membrane [J]. ACS Applied Materials & Interfaces, 2019, 11, 15133-15140.
19. Juan Qiao, Qianrong Liu, Han Wu, Huiwu Cai, Li Qi*, Non-enzymatic detection of serum glucose using a fluorescent nanopolymer probe [J]. Microchimica Acta, 2019, 186, 366.
20. Juan Qiao, Liping Zhao, Lili Liu, Li Qi*, L-Glutaminase enzyme reactor based on porous bamboo sticks and its application in enzyme inhibiters screening [J].Talanta, 2019, 205, 120126.
21. Wenya Feng, Juan Qiao*, Dan Li, Li Qi*, Chiral ligand exchange capillary electrochromatography with dual ligands for enantioseparation of D,L-amino acids [J].Talanta, 2019, 194, 430-436.
22. Juan Qiao, Chuanfang Chen, Dihua Shangguan, Xiaoyu Mu, Shutao Wang, Lei Jiang*, Li Qi*, Simultaneous monitoring of mitochondrial temperature and ATP fluctuation using fluorescent probes in living cells [J]. Analytical Chemistry, 2018, 90, 12553-12558.
V. 发明专利和软件著作权
1. 乔娟，曹俊阳，张竞丹，李浩玉，张荣月，一种聚合物修饰环糊精MOFs材料及其制备方法和毛细管电泳手性分离方法，中华人民共和国发明专利, ZL202311609129.8
2. 齐莉, 沈吉, 乔娟, 刺激响应聚合物基质D-氨基酸氧化酶反应器的制备及其酶解效率调控方法，中华人民共和国发明专利, ZL202110463264
3. 齐莉, 乔娟, 李雅萍, 木肖玉, 一种固定化L-天冬酰胺酶反应器，中华人民共和国发明专利, ZL201210137793.2
VI. 出版著作
1. 王可，乔娟，《光学探针与传感分析》马会民主编 (第11章), 2020, 448-472
2. Juan Qiao, Li Qi. Design and preparation of stimuli-responsive AIE fluorescent polymers-based probes for cells imaging, Handbook of Aggregation, 2022
VII. 研究生指导情况
在读研究生10名，毕业研究生1名，辅助指导多名联培硕士生，教授《高级生物化学》研究生必修课程
