
郭前进,教授,2008年毕业于中国科学院沈阳自动化研究所,获机械电子工程博士学位,美国波士顿大学任高级访问学者(2019-2020)。长期致力于智能装备与系统、人工智能、智能检测技术及生物医药制造等交叉领域研究。主持或参与国家自然科学基金面上项目、国家自然科学基金国际合作项目、国家863专项、国家重大科研仪器研制项目及省部级项目等纵向课题20余项。现任中国中医药信息学会智能诊疗分会理事、北京能源与环境学会专家委员会委员,担任 International Journal of Molecular Sciences 等国际期刊编委,以及 Nature Biomedical Engineering、Nature Communications、Advanced Science、Information Fusion、Computers in Industry、Cell Genomics、Engineering Applications of Artificial Intelligence、Environmental Science & Technology、IEEE 等数十种国际权威期刊与会议审稿专家。累计发表学术论文100余篇,申请专利及软件著作权20余项。曾获中国科学院院长奖、澳大利亚BHBP奖、中科院知识创新冠名奖、市级科技进步一等奖等多项荣誉。在研究生培养方面,已指导硕士生30余名、博士生3名,多人荣获国家奖学金、市优秀研究生等科研奖励;所指导的研究生相继被中国科学院、复旦大学、东南大学、北京理工大学、中国矿业大学、北京协和医院、北京交通大学等国内顶尖高校与科研机构录取为博士研究生。
1.智能装备与系统
2.人工智能
3.光电技术
4.生物医学成像
5.超快光谱学
[1] Mengqiu Wang, Zhiwei Zhang, Xinxin Zhang, Zhenghui Wang, Ruoyan Dai, Zeyao Chen, Lixin Lei, Zhenxing Li, Qianjin Guo*, et al. STELLA: A spatial transcriptomics framework for microenvironment decoding using dynamic graph neural networks. SCIENCE CHINA Life Sciences, 2026, doi:10.1007/s11427-025-3126-7.
[2] Zhenghui Wang, Ruoyan Dai, Kaitai Han, Mengqiu Wang, Lixin Lei, Zhiwei Zhang, Zhenxing Li, Xingyu Liu, Jirui Zhang, Han Yan, Qianjin Guo* et al. MNiST: A Deep Learning Framework for Multi-Scale Spatial Feature Modeling and Cellular Landscape Decoding in Spatial. Knowledge-Based Systems, 2025, 328: 114233.
[3] Zhenghui Wang, Ruoyan Dai, Mengqiu Wang, Lixin Lei, Zhenxing Li, Zhiwei Zhang, Qianjin Guo*. SpatioFreq: A Deep Learning Framework for Decoding Cellular and Tissue Landscapes Across Organisms Using Spatial Transcriptomics. Interdiscip Sci Comput Life Sci, 2026. https://doi.org/10.1007/s12539-025-00811-6.
[4] Xingyu Liu, Yunfeng Li, Yijia Liu, Jun Yuan, Tianhao Liu, Maoyuan Zhou, Jiaxing Li, Zhiwei Zhang, Xiaoqing Wang, Tiantian Ma, Nasrollah Moghadam, Hossein Ganjidoust, Qianjin Guo*, et al. PRISM: Synergistic Modality Fusion with Equivariant Graph Neural Networks for RNA-Ligand Interaction Prediction. European Journal of Medicinal Chemistry, 2026, 313: 118795. http://dx.doi.org/10.1016/j.ejmech.2026.118795.
[5] Mengqiu Wang, Zhiwei Zhang, Xinxin Zhang, Ruoyan Dai, Zhenghui Wang, Zeyao Chen, Lixin Lei, Zhenxing Li, Qianjin Guo*. SpatialFusion: A Unified Model for Integrating Spatial Transcriptomics to Unveil Cell-type Distribution, Interaction, and Functional Heterogeneity in Tissue Microenvironments. Journal of Molecular Biology, 2026, 438: 169535.
[6] Tianhao Liu, Yijia Liu, Xingyu Liu, Yunfeng Li, Jun Yuan, Sirui Wang, Xiaozhu Lin, Qianjin Guo*. CausalTCC: causal temporal contrastive learning for automated Alzheimer's disease biomarker discovery with bio-electrical signals. Journal of Neural Engineering, 2026. DOI: 10.1088/1741-2552/ae8578.
[7] Xiaorui Huang, Zijun Wang, Xingyu Liu, Jiaxing Li, Jiaqi Zhu, Maoyuan Zhou, Jirui Zhang, Qianjin Guo*. Hybrid Self-Supervised learning for brain tumor analysis in Stimulated Raman Histology. Biomedical Signal Processing and Control, 2026, 122: 110483.
[8] Ruoyan Dai, Zhenghui Wang, Zhiwei Zhang, Lixin Lei, Mengqiu Wang, Zhenxing Li, Xingyu Liu, Qianjin Guo*e. A multi-scale graph frequency network for structural and functional region analysis in spatial transcriptomics. Funct Integr Genomics, 2026, 26: 176.
[9] Xingyu Liu, Xiaorui Huang, Jirui Zhang, Maoyuan Zhou, Jiaxing Li, Zhiwei Zhang, Tianhao Liu, Zhenghui Wang, Nasrollah Moghadam, Hossein Ganjidoust, Qianjin Guo*. MutiDTAGen: fusion framework of perceptual new drug generation and drug-target affinity prediction through multi-scale feature extraction. Journal of Computer-Aided Molecular Design, 2026, 40: 41.
[10] Xingyu Liu, Maoyuan Zhou, Xiaorui Huang, Jirui Zhang, Jiaxing Li, Zhenghui Wang, Lixin Lei, Kaitai Han, Nasrollah Moghadam, Hossein Ganjidoust, Qianjin Guo*. HopWD-DTA: a novel framework for drug-target affinity prediction fusing multi-hop neighborhoods and deep features. Journal of Molecular Modeling, 2026, 32: 127.
[11] Xiaoqing Wang, Xingyu Liu, Zhiwei Zhang, Maoyuan Zhou, Tiantian Ma, Yijia Liu, Jun Yuan, Tianhao Liu, Yunfeng Li,Qianjin Guo*. CABA-Bind: Confounder-Aligned Backdoor Adjustment for Debiased RNA-Ligand Binding Prediction. Computational Biology and Chemistry, 2026: 109293. doi:10.1016/j.compbiolchem.2026.109293.
[12] Jirui Zhang, Xingyu Liu, Maoyuan Zhou, Xiaorui Huang, Jiaxing Li, Ruoyan Dai, Nasrollah Moghadam, Hossein Ganjidoust,Qianjin Guo*. DSSMST: A Deterministic State Space Model for Self-Supervised Spatial Domain Identification in Spatial Transcriptomics. Biochem Genet, 2026. https://doi.org/10.1007/s10528-026-11441-y.
[13] Xiaorui Huang, Xingyu Liu, Maoyuan Zhou, Jiaqi Zhu, Jiaxing Li, Yijia Liu, Tianhao Liu, Zhiwei Zhang, Zhenghui Wang, Qianjin Guo*. TransGAT-DTA: A multi-task framework for drug–target affinity prediction and conditional molecule generation. Biochemical and Biophysical Research Communications, 2026, 800: 153292.
[14] Zhiwei Zhang, Mengqiu Wang, Xinxin Zhang, Ruoyan Dai, Zhenghui Wang, Lixin Lei, Zhenxing Li, Kaitai Han, Zijun Wang, Chaojing Shi, Qianjin Guo*, et al. SpaOmicsVAE: A Deep Learning Framework for Integrative Analysis of Spatial Multi-omics Data. Computer Methods and Programs in Biomedicine, 2025,271: 109032.
[15] Zhenxing Li, Kaitai Han, Zijun Wang, Lixin Lei,Zhenghui Wang,Ruoyan Dai, Mengqiu Wang, Zhiwei Zhang, Qianjin Guo*, et al. Enhanced inhibitor–kinase affinity prediction via integrated multimodal analysis of drug molecule and protein sequence features. International Journal of Biological Macromolecules, 2025, 309: 142871.
[16] Zhenghui Wang, Ruoyan Dai, Mengqiu Wang, Lixin Lei, Zhiwei Zhang, Kaitai Han, Zijun Wang, Qianjin Guo*, et al. KanCell: dissecting cellular heterogeneity in biological tissues through integrated single-cell and spatial transcriptomics. Journal of Genetics and Genomics, 2025, 52(5): 689-705.
[17] Ruoyan Dai, Zhenghui Wang, Zhiwei Zhang, Lixin Lei, Mengqiu Wang, Kaitai Han, Zijun Wang, Zhenxing Li, Jirui Zhang, Qianjin Guo*. GraphCellNet: A deep learning method for integrated single-cell and spatial transcriptomic analysis with applications in development and disease. Journal of Molecular Medicine, 2025, 103: 1087-1111.(封面文章)
[18] Zijun Wang , Xi Liu*, Kaitai Han, Lixin Lei, Chaojing Shi, Wu Liu, Qianjin Guo*, et al. Multimodal deep learning for immunotherapy response prediction and biomarker discovery in non-small cell lung cancer. Journal of the American Medical Informatics Association, 2025,32(11): 1641-1653.
[19] Maoyuan Zhou, Jingjie He, Xingyu Liu, Junmin Huang, Jirui Zhang, Jiaxing Li, Xiaorui Huang, Qianjin Guo*, et al. A semantic framework for drug-target affinity prediction using Mamba and graph convolutional networks for multimodal feature fusion. Chemometrics and Intelligent Laboratory Systems, 2026,269:105601. doi:10.1016/j.chemolab.2025.105601.
[20] Maoyuan Zhou, Jingjie He, Xingyu Liu, Junmin Huang, Jirui Zhang, Jiaxing Li, Xiaorui Huang, Qianjin Guo*, et al. Affinity prediction of inhibitor-kinase based on mixture of experts enhanced by multimodal feature semantic analysis. International Journal of Biological Macromolecules, 2025,321(2): 146324.
[21] Mengqiu Wang, Zhiwei Zhang, Lixin Lei, Kaitai Han, Zhenghui Wang, Ruoyan Dai, Zijun Wang, Chaojing Shi, Xudong Zhao, Qianjin Guo*. VARGG: a deep learning framework advancing precise spatial domain identification and cellular heterogeneity analysis in spatial transcriptomics. Briefings in Functional Genomics, 2025, 24: elaf018.
[22] Lixin Lei, Qianjin Guo*, Wu Liu, Zijun Wang, Kaitai Han, Chaojing Shi, Zhenxing Li, Sichao Lu, Mengqiu Wang, Zhiwei Zhang, Ruoyan Dai, Zhenghui Wang, Xingyu Liu. A novel deep learning framework for predicting protein-ligand interaction fingerprints from sequence data: integrating graph inductive bias transformer with Kolmogorov-Arnold networks. Computational Toxicology, 2025, 36: 100386.
[23] Shitou Liu, Guocheng Sun, Xi Liu, Qianjin Guo*, et al. Architectural order identification across label-free living cell imaging with a swin transformer-conditional GAN. Biomedical Physics & Engineering Express, 2025, 11(3): 035001.
[24] Zhiwei Zhang, Mengqiu Wang, Ruoyan Dai, Zhenghui Wang, Lixin Lei, Xudong Zhao, Kaitai Han, Chaojing Shi, Qianjin Guo*. GraphCVAE: Uncovering cell heterogeneity and therapeutic target discovery through residual and contrastive learning. Life Sciences, 2024, 359: 123208. https://doi.org/10.1016/j.lfs.2024.123208.
[25] Mengyuan Huang, Kaitai Han, Wu Liu, Zijun Wang, Xi Liu, Qianjin Guo*, et al. Advancing microplastic surveillance through photoacoustic imaging and deep learning techniques. Journal of Hazardous Materials, 2024, 470: 134188.
[26] Kaitai Han, Chaojing Shi, Zijun Wang, Wu Liu, Zhenxing Li, Zhenghui Wang, Lixin Lei, Ruoyan Dai, Mengqiu Wang, Zhiwei Zhang, Qianjin Guo*. Innovative Mamba and graph transformer framework for superior protein-ligand affinity prediction. Microchemical Journal, 2024, 206: 111444. https://doi.org/10.1016/j.microc.2024.111444.
[27] Kaitai Han, Mengyuan Huang,Zhenghui Wang,Chaojing Shi,Zijun Wang,Qianjin Guo*, et al. Innovative methods for microplastic characterization and detection: Deep learning supported by photoacoustic imaging and automated pre-processing data. Journal of Environmental Management, 2024, 359: 120954.
[28] Zijun Wang, Kaitai Han, Wu Liu, Zhenghui Wang, Chaojing Shi, Xi Liu, Mengyuan Huang, Guocheng Sun, Shitou Liu, Qianjin Guo*, et al. Fast real-time brain tumor detection based on stimulated raman histology and self-supervised deep learning model. Journal of Imaging Informatics in Medicine, 2024, 37(3): 1160-1176.
[29] Kaitai Han, Xi Liu, Guocheng Sun, Zijun Wang, Chaojing Shi, Wu Liu, Mengyuan Huang, Shitou Liu, Qianjin Guo*. Enhancing subcellular protein localization mapping analysis using Sc2promap utilizing attention mechanisms. Biochimica et Biophysica Acta (BBA) - General Subjects, 2024, 1868(6): 130601.
[30] Lixin Lei, Kaitai Han, Zijun Wang, Chaojing Shi, Zhenghui Wang, Ruoyan Dai, Zhiwei Zhang, Mengqiu Wang, Qianjin Guo*. Attention-guided variational graph autoencoders reveal heterogeneity in spatial transcriptomics. Briefings in Bioinformatics, 2024, 25(3): bba0173.
[31] Chaojing Shi, Guocheng Sun, Kaitai Han, Mengyuan Huang, Wu Liu, Xi Liu, Zijun Wang, Qianjin Guo*. Reconstructing 3D Biomedical Architectural Order at Multiple Spatial Scales with Multimodal Stack Input. Journal of Bionic Engineering, 2024, 21: 2587-2601.
[32] Mengyuan Huang, Wu Liu, Guocheng Sun, Chaojing Shi, Xi Liu, Kaitai Han, Shitou Liu, Zijun Wang, Zhennian Xie, Qianjin Guo*. Unveiling precision: a data-driven approach to enhance photoacoustic imaging with sparse data. Biomedical Optics Express, 2024, 15(1): 28-43.
[33] Guocheng Sun, Shitou Liu, Chaojing Shi, Xi Liu, Qianjin Guo*, et al. 3DCNAS: A universal method for predicting the location of fluorescent organelles in living cells in three-dimensional space. Experimental Cell Research, 2023: 113807.
[34] 刘茜, 韩凯泰, 黄梦圆, 刘石头, 郭前进*. 人工智能在透明病理学中的应用研究进展. 磁共振成像, 2023, 14(10): 195-202.
[35] Zhihao Wei, Wu Liu, Weiyong Yu, Xi Liu, Ruiqing Yan, Qianjin Guo*, et al. Multiple Parallel Fusion Network for Predicting Protein Subcellular Localization from Stimulated Raman Scattering (SRS) Microscopy Images in Living Cells. Int J Mol Sci, 2022, 23(18): 10827.
[36] Zhihao Wei, Xi Liu, Ruiqing Yan, Guocheng Sun, Qianjin Guo*, et al. Pixel-level multimodal fusion deep networks for predicting subcellular organelle localization from label-free live-cell imaging. Front Genet, 2022, 13: 1002327.
课题组主要招收控制科学与工程(0811)学术学位硕士、电子信息(0854)专业学位硕士。诚挚欢迎人工智能、计算机科学与技术、智能装备与系统、光学工程、机械电子工程等专业踏实认真、敢于创新、具备较强计算机应用能力和较高英语水平的同学加入本团队。